Bilirubin is a breakdown product that is produced when the hemoglobin in red blood cells is broken down and is measured to check the health of your liver.
Bilirubin is yellow in color
Bilirubin is a breakdown product. High levels of bilirubin can indicate that your liver is not functioning properly.
Brief about bilirubin
- Bilirubin gives stool and urine their color.
- Bilirubin is a breakdown product.
- High levels can indicate that the liver is not functioning properly.
P-Bilirubin
Bilirubin is a breakdown product (waste product) produced when hemoglobin in red blood cells is broken down. A bilirubin blood test is used to check the health of your liver.
High levels of bilirubin can indicate that your liver is not functioning properly. It can also be a sign of hemolytic anemia, which means that the body is destroying red blood cells faster than they are produced. Bilirubin levels may increase in connection with blood transfusion, hepatitis, cirrhosis, metastases, various inflammations, surgical injuries, liver tumors, and cell damage.
Low levels of bilirubin rarely have medical significance.
An out-of-range result does not always mean that you have a medical condition requiring treatment. An elevated value may also be due to the time of day the test is taken (the value can be twice as high in the morning as in the afternoon), medication, certain foods, or strenuous exercise. Your doctor will assess your levels in relation to other test results.
Bilirubin is yellow, which can be seen in the skin and whites of the eyes of people with jaundice who have very high levels of bilirubin in their blood. The yellow color also appears in old bruises that have turned yellow.
When might a bilirubin test be of interest?
- In the analysis of liver health
- In symptoms such as jaundice, dark urine, or abdominal pain
- To determine if there is blockage in the bile ducts
- To investigate any disorders related to problems breaking down red blood cells
To review your liver health, we recommend that bilirubin be supplemented with ASAT, ALAT, GT, and ALP.
Reference values for bilirubin
Women and men 18 years and older: <26 µmol/L
Reference values may vary depending on where the analysis is performed, and which analysis method is used.
FAQ
Liver transplantation is a treatment option intended for patients with severe liver failure or certain liver diseases that do not respond to other treatments. Liver transplantation may be an option for end-stage liver cirrhosis, acute liver failure, or certain genetic liver diseases. The suitability of a patient for liver transplantation is carefully assessed, and factors such as the patient’s overall health condition and other possible diseases influence the decision.
The rate of liver recovery depends on the extent of the damage and the individual’s health condition. A healthy liver can regenerate and repair damage effectively, but recovery can take weeks or months.
Liver values can be elevated for many reasons, such as excessive alcohol use, side effects of medication, fatty liver, or hepatitis. Elevated values may indicate liver dysfunction.
An adult human liver weighs on average about 1–1.5 kilograms. The liver is the largest internal organ in the body.
Symptoms of liver cancer can include abdominal pain, especially under the right rib cage, weight loss, loss of appetite, jaundice (yellowing of the skin and eyes), and general fatigue. Symptoms can be nonspecific and may be confused with other liver diseases.
To reduce bilirubin, it is important to treat the underlying causes of its elevation. This may include medication, lifestyle changes, or more specialized treatments depending on the underlying disease, such as liver diseases.
The decrease in liver values depends on many factors, such as the original reason for the increase and the individual’s health condition. Generally, with healthy lifestyle choices and treatment of any underlying diseases, liver values can start to normalize within a few weeks.
An ALAT value is considered too high when it exceeds the laboratory’s reference values, which are usually about 10–70 U/L for men and 7–45 U/L for women. High values can indicate liver diseases such as hepatitis or fatty liver, but other factors such as obesity, diabetes, or excessive alcohol use can also raise ALAT values.
Normal values for GT (gamma-glutamyl transferase) vary by age and gender, but generally are under 60 U/L for men and under 40 U/L for women. High values may indicate liver or bile duct problems.
Lowering liver values often requires lifestyle changes, such as limiting alcohol consumption, a healthy diet, and exercise. In some cases, medication or other medical treatment may be necessary.
To lower the ALAT value, it is important to identify and treat the cause of its increase. Common ways to reduce the value include following a healthy and balanced diet, reducing or stopping alcohol consumption, and regular exercise. It is also advisable to avoid medications and other substances that can strain the liver. If the ALAT value is significantly elevated, it is advisable to consult a doctor who can prescribe appropriate treatment.
The diagnosis of cirrhosis is based on symptoms, medical examination, and results from laboratory tests, such as liver function tests. Ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) can help assess the condition of the liver. A liver biopsy may also be performed if necessary.
Liver disease can cause yellowing of the skin and eyes, itching, dark patches on the skin, or small, spiderweb-like vascular changes on the skin.
Symptoms of cirrhosis can initially be vague and mild, such as fatigue and loss of appetite. As the disease progresses, it can cause jaundice, abdominal swelling (ascites), itching, and bleeding from the gastrointestinal tract. Spider angiomas on the skin are also typical.
Gallbladder issues can manifest in various ways. Common symptoms include upper abdominal pain that may radiate to the back or right shoulder, nausea, and vomiting. Symptoms can worsen after eating fatty foods. In some cases, jaundice may also occur as bile accumulates in the body.
Fatty liver is typically diagnosed through blood tests, such as liver values and fat levels, and imaging studies, such as ultrasound or computed tomography.
Cirrhosis can appear on the skin in several ways. Typical manifestations include jaundice, spider angiomas (small patterns formed by blood vessels on the skin), and skin itching. Additionally, yellowing of the skin and the whites of the eyes (icterus) is a common symptom.
Liver dysfunction can manifest in various ways, such as fatigue, yellowing of the skin and eyes (jaundice), abdominal pain, and swelling. Symptoms depend on the type and severity of liver disease.
The ALAT value can decrease from a few days to weeks depending on what has caused the increase. For example, reducing or stopping alcohol consumption, a healthier diet, and regular exercise can accelerate the decrease in the ALAT value. If the ALAT value has increased due to liver disease, lowering the value may take longer and require treatment prescribed by a doctor.
Fatty liver can be asymptomatic for a long time, but in some cases, it may cause fatigue, upper abdominal pain, or swelling. The diagnosis is usually confirmed through blood tests and imaging studies.
The treatment for fatty liver primarily involves lifestyle changes: a healthy diet, regular exercise, and weight loss if necessary. Reducing or stopping alcohol consumption is also important.
Liver cirrhosis usually progresses slowly over the years. In the initial phase, cirrhosis can be asymptomatic, but as liver function deteriorates, it can lead to serious complications such as internal bleeding, kidney failure, and liver failure.
ALAT – reference values and liver health
Alanine aminotransferase (ALAT) is an indicator of the well-being of the liver. It reacts to long-term alcohol use and fatty liver disease caused by excess weight, for example.
ALP (alkaline phosphatase) is an enzyme found in liver cells
ALP is the abbreviation for the enzyme alkaline phosphatase, which is primarily found in the liver, bile ducts, and bones. It is therefore common to measure ALP when examining the health of the liver, associated bile ducts, and skeleton.
ASAT, or aspartate aminotransferase, indicates the condition of the liver
High ASAT may indicate tissue damage in important organs.
GT is a liver enzyme that describes the health of the liver
GT is one of the standard tests used to assess the health of the liver and bile ducts, especially when there is suspicion of alcohol-related health issues. More GT is produced by liver cells when they are under stress, such as in liver diseases or heavy alcohol consumption.
LDL is a “bad” cholesterol
The LDL cholesterol level shows the amount of harmful cholesterol in the blood.
Monocytes are white blood cells
White blood cells are an important part of the human immune system. They protect the body from attacks of bacteria, viruses, and parasites. Bone marrow produces five different types of white blood cells, one of which is the monocyte.
Article updated:
23 October 2024