GT is one of the standard tests for examining the health of the liver and bile ducts, especially when there is suspicion of alcohol-related health issues.
ASAT, or aspartate aminotransferase, indicates the condition of the liver
High ASAT may indicate tissue damage in important organs.
ASAT
- The ASAT value indicates the state of health of tissues.
- ASAT increases during acute inflammations and in the case of tissue damage.
- The ASAT test allows for assessing the state of health of the heart, pancreas and liver.
- High ASAT can be restored to normal by treating the cause of the high level.
What is aspartate aminotransferase?
ASAT, or aspartate aminotransferase, is an enzyme found in the liver, pancreas and heart. Its concentration is increased in the case of tissue damage to important organs, such as cirrhosis of the liver or myocardial infarction. The enzyme enters the bloodstream as a result of the damage.
The aspartate aminotransferase level can also be high, for example, in the case of hepatitis and pancreatitis.
Aspartate aminotransferase is an enzyme that is responsible for the conversion of alpha-ketoglutarate into oxaloacetate and glutamate in the body. Glutamate is a neurotransmitter that stimulates brain activity and is involved in nerve cell growth, differentiation, learning and movement regulation.
Oxaloacetate has several functions in the body. For example, it acts as a precursor in gluconeogenesis, a process that takes place in the liver and in the cortex of the kidney, where glucose is made from substances other than carbohydrates.
The highest concentrations of this enzyme are found in the liver, heart muscle and muscles, i.e. the organs where metabolism is rapid. The concentration increases in the case of acute diseases and heart muscle damage.
ASAT test P-ASAT
The result of the ASAT study says a lot about the tissues’ state of health as a high value indicates the breakdown of the tissues.
The ASAT value can be used to determine the following diseases:
- Differential hepatitis diagnosis of hepatitis based on ASAT/ALAT ratio
- Diagnosis of liver diseases
- As an additional study in the diagnostics of muscle diseases
The reference values for ASAT
Men have, on average, slightly higher ASAT levels than women. The ASAT level increases with age. The level is usually higher in the case of obesity.
Women, 18 years old or older: 0,25 – 0,60 µkat/L
Men, 18 years old or older: 0,25 – 0,75 µkat/L
Reference levels may vary depending on the laboratory and the test analysis method.
What are the reasons for abnormal ASAT levels?
- Acute hepatitis, in which ASAT can increase up to 20 times the reference value.
- Gallstones can cause ASAT to become ten times the reference value, but the level also returns to normal very quickly after the condition has been corrected.
- Liver cirrhosis. The ASAT level varies according to the extent of damage.
- Acute myocarditis
- Progressive muscular dystrophy and dermatomyositis
- Hemolysis, i.e. the breakdown of red blood cells, may cause falsely high ASAT values.
ASAT/ALAT ratio
The ratio of aspartate aminotransferase and alanine aminotransferase can be interpreted to determine the quality of hepatitis as follows:
- Viral, drug and autoimmune hepatitis: ratio usually less than 1, i.e. ASAT is lower than ALAT
- Significant liver damage, such as toxic, ischaemic or other severe hepatitis: ratio usually higher than 1
- Alcoholic hepatitis: high ASAT/ALAT ratio, up to more than 2
A high ASAT/ALAT ratio may also be due to extrahepatic tissues. The ratio is often high in the case of muscular dystrophy, muscle exertion, pulmonary embolism and kidney infection.
Treatment of high ASAT
The aim is to restore the abnormal ASAT value close to the reference value by treating the condition that causes the increase. If the high value is due to alcohol consumption, drinking must be stopped. If the high value is due to another disease, treating the disease decreases the value.
FAQ
Liver transplantation is a treatment option intended for patients with severe liver failure or certain liver diseases that do not respond to other treatments. Liver transplantation may be an option for end-stage liver cirrhosis, acute liver failure, or certain genetic liver diseases. The suitability of a patient for liver transplantation is carefully assessed, and factors such as the patient’s overall health condition and other possible diseases influence the decision.
The rate of liver recovery depends on the extent of the damage and the individual’s health condition. A healthy liver can regenerate and repair damage effectively, but recovery can take weeks or months.
Liver values can be elevated for many reasons, such as excessive alcohol use, side effects of medication, fatty liver, or hepatitis. Elevated values may indicate liver dysfunction.
An adult human liver weighs on average about 1–1.5 kilograms. The liver is the largest internal organ in the body.
Symptoms of liver cancer can include abdominal pain, especially under the right rib cage, weight loss, loss of appetite, jaundice (yellowing of the skin and eyes), and general fatigue. Symptoms can be nonspecific and may be confused with other liver diseases.
To reduce bilirubin, it is important to treat the underlying causes of its elevation. This may include medication, lifestyle changes, or more specialized treatments depending on the underlying disease, such as liver diseases.
The decrease in liver values depends on many factors, such as the original reason for the increase and the individual’s health condition. Generally, with healthy lifestyle choices and treatment of any underlying diseases, liver values can start to normalize within a few weeks.
An ALAT value is considered too high when it exceeds the laboratory’s reference values, which are usually about 10–70 U/L for men and 7–45 U/L for women. High values can indicate liver diseases such as hepatitis or fatty liver, but other factors such as obesity, diabetes, or excessive alcohol use can also raise ALAT values.
Normal values for GT (gamma-glutamyl transferase) vary by age and gender, but generally are under 60 U/L for men and under 40 U/L for women. High values may indicate liver or bile duct problems.
Lowering liver values often requires lifestyle changes, such as limiting alcohol consumption, a healthy diet, and exercise. In some cases, medication or other medical treatment may be necessary.
To lower the ALAT value, it is important to identify and treat the cause of its increase. Common ways to reduce the value include following a healthy and balanced diet, reducing or stopping alcohol consumption, and regular exercise. It is also advisable to avoid medications and other substances that can strain the liver. If the ALAT value is significantly elevated, it is advisable to consult a doctor who can prescribe appropriate treatment.
The diagnosis of cirrhosis is based on symptoms, medical examination, and results from laboratory tests, such as liver function tests. Ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) can help assess the condition of the liver. A liver biopsy may also be performed if necessary.
Liver disease can cause yellowing of the skin and eyes, itching, dark patches on the skin, or small, spiderweb-like vascular changes on the skin.
Symptoms of cirrhosis can initially be vague and mild, such as fatigue and loss of appetite. As the disease progresses, it can cause jaundice, abdominal swelling (ascites), itching, and bleeding from the gastrointestinal tract. Spider angiomas on the skin are also typical.
Gallbladder issues can manifest in various ways. Common symptoms include upper abdominal pain that may radiate to the back or right shoulder, nausea, and vomiting. Symptoms can worsen after eating fatty foods. In some cases, jaundice may also occur as bile accumulates in the body.
Fatty liver is typically diagnosed through blood tests, such as liver values and fat levels, and imaging studies, such as ultrasound or computed tomography.
Cirrhosis can appear on the skin in several ways. Typical manifestations include jaundice, spider angiomas (small patterns formed by blood vessels on the skin), and skin itching. Additionally, yellowing of the skin and the whites of the eyes (icterus) is a common symptom.
Liver dysfunction can manifest in various ways, such as fatigue, yellowing of the skin and eyes (jaundice), abdominal pain, and swelling. Symptoms depend on the type and severity of liver disease.
The ALAT value can decrease from a few days to weeks depending on what has caused the increase. For example, reducing or stopping alcohol consumption, a healthier diet, and regular exercise can accelerate the decrease in the ALAT value. If the ALAT value has increased due to liver disease, lowering the value may take longer and require treatment prescribed by a doctor.
Fatty liver can be asymptomatic for a long time, but in some cases, it may cause fatigue, upper abdominal pain, or swelling. The diagnosis is usually confirmed through blood tests and imaging studies.
The treatment for fatty liver primarily involves lifestyle changes: a healthy diet, regular exercise, and weight loss if necessary. Reducing or stopping alcohol consumption is also important.
Liver cirrhosis usually progresses slowly over the years. In the initial phase, cirrhosis can be asymptomatic, but as liver function deteriorates, it can lead to serious complications such as internal bleeding, kidney failure, and liver failure.
The aspartate aminotransferase (ASAT) test measures liver function and damage.
Alanine aminotransferase (ALAT) is an indicator of the well-being of the liver and reacts, for example, to long-term alcohol use and fatty liver disease caused by excess weight.
ALAT – reference values and liver health
Alanine aminotransferase (ALAT) is an indicator of the well-being of the liver. It reacts to long-term alcohol use and fatty liver disease caused by excess weight, for example.
ALP (alkaline phosphatase) is an enzyme found in liver cells
ALP is the abbreviation for the enzyme alkaline phosphatase, which is primarily found in the liver, bile ducts, and bones. It is therefore common to measure ALP when examining the health of the liver, associated bile ducts, and skeleton.
GT is a liver enzyme that describes the health of the liver
GT is one of the standard tests used to assess the health of the liver and bile ducts, especially when there is suspicion of alcohol-related health issues. More GT is produced by liver cells when they are under stress, such as in liver diseases or heavy alcohol consumption.
Albumin reflects the body’s fluid balance
Albumin is produced in the liver and has two important functions: regulating the body’s fluid levels and transporting essential nutrients to the body’s tissues. Reduced levels of albumin can be seen in conditions such as physical inactivity and malnutrition.
Bilirubin is yellow in color
Bilirubin is a breakdown product. High levels of bilirubin can indicate that your liver is not functioning properly.
Urea
Urea is a waste product formed when the body breaks down amino acids and proteins from the food we ingest.
Article updated:
23 October 2024