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Mean corpuscular volume of red blood cells (MCV)
MCV is tested when looking for the causes of diagnosed anemia.
MCV
- MCV test measures the average size of red blood cells.
- MCV is tested when looking for the causes of diagnosed anemia.
- Anemia is classified as microcytic, macrocytic, or normocytic.
- In normocytic anemias, the volume of red blood cells is normal, but the hemoglobin level is low.
What is mean corpuscular volume of red cells (MCV)?
The mean corpuscular volume of red blood cells known as MCV indicates the average size of the red blood cells.
MCV is tested for example when looking for the causes of diagnosed anemia. Anemia is classified as microcytic if the MCV is below reference values, macrocytic if the MCV is above reference values, and normocytic if the MCV falls within the reference values.
Reference values for MCV
MCV indicates the volume, or size, of the red blood cells.
Reference levels may vary depending on the laboratory and the test analysis method.
Low MCV value
Low MCV value is a sign of microcytic anemia.
Microcytic anemia
Microcytic anemias include:
- iron deficiency anemia
- haemoglobinopathies (such as sickle cell anemia)
- sideroblastic anemia
Iron deficiency anemia is by far the most common type of anemia and can be caused, for example, by prolonged blood loss due to heavy menstruation or intestinal bleeding. It may also be caused by giving birth, donating blood, or poor absorption of iron. Iron deficiency can also occur when a person does not get enough iron in their diet.
Normal MCV value in conjunction with anemia
In normocytic anemias, the volume of red blood cells is normal, but the hemoglobin level is low.
Normocytic anemia
In normocytic anemias, the volume of red blood cells is normal, but their number is small.
Normocytic anemias include:
- anemia due to bleeding
- anemia associated with long-term illness
- hemolytic anemia
- aplastic anemia
High MCV value
High MCV value is a sign of macrocytic anemia.
Macrocytic anemia
Macrocytic anemias include:
- Megaloblastic anemia caused by vitamin B12 deficiency
- Pernicious anemia, in which the vitamin B12 deficiency is caused by malabsorption resulting from an autoimmune disease
High MCV values can also be caused by folic acid deficiency.
If a working-age person has a normal hemoglobin level but elevated MCV, the reason is usually alcoholism. Cutting back alcohol consumption lowers the MCV value, but this takes months.
Potassium is an essential salt for the body. It regulates, among other things, the body’s fluid balance.
Magnesium is an essential mineral for the body. It is needed for the functioning of the nervous system and several enzymes.
Iron is needed for the formation of red blood cells’ haemoglobin. In addition, it acts as a catalyst in many enzyme reactions.
Folate, or folic acid, is a group B vitamin obtained from food. It is an essential nutrient for humans.
The aspartate aminotransferase (ASAT) test measures liver function and damage.
T4, or thyroxine, is a thyroid hormone and its level indicates the activity of the thyroid gland.
Glucose is an indicator of the blood sugar level. Blood sugar affects general well-being and energy levels, muscle and brain function and the feeling of hunger.
The LDL cholesterol level shows the amount of harmful cholesterol in the blood. Elevated cholesterol increases the risk of atherosclerosis.
Sodium is one of the most important salts in the body. It is essential for life, being a key substance in maintaining the membrane tension of all cells.
TSH or thyroid-stimulating hormone is secreted by the pituitary gland. TSH is tested when examining thyroid function.
Ferritin is a form of iron absorption and storage. It is a good measure of the body’s iron stores, and low ferritin content is a sign of iron deficiency.
Basophils are white blood cells
Basophils are white blood cells that fight parasitic diseases, prevent unnecessary blood clotting, and mediate allergic reactions.
Creatinine (Crea)
Creatinine value helps assess kidney function.
Eosinophils are white blood cells
Eosinophils play a particularly important role in reactions related to allergies, allergic dermatitis, and asthma.
Erythrocytes or red blood cell count
The number of red blood cells is examined in connection with a blood count. In cases of anemia, the number of red blood cells is low.
Leukocytes – Reference values and general information about white blood cells
White blood cells fight viruses, bacteria, parasites, and other intruders that threaten the health of the body.
Hemoglobin (Hb) – Measurement and reference values
When suspecting anemia, it is important to test the hemoglobin. Symptoms of iron deficiency anemia include paleness and fatigue.
Article updated:
19 February 2024
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