The timing of taking selenium can affect its absorption and benefits. Generally, it is best to take selenium with a meal as food improves its absorption. It is advisable to consume selenium as part of a balanced diet that includes a variety of vitamins and minerals. This helps ensure that you get the maximum benefit from selenium. Additionally, it is good to note that taking selenium in the evening can disturb sleep in some people, so the morning or early afternoon may be a better time to take it.